DNA repair regulates chromatin structure and key transcription factors
نویسندگان
چکیده
منابع مشابه
Ubiquitin regulates dissociation of DNA repair factors from chromatin
Involvement of the ubiquitin system in DNA repair and DNA damage signaling has been extensively studied during the last decade. Dynamic modification of proteins with ubiquitin after DNA damage has been shown to play important roles in virtually all DNA repair pathways [1]. In this regard, protein ubiquitylation has most frequently been associated with the recruitment of DNA repair factors – man...
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It is well accepted that non-coding RNAs play a critical role in regulating gene expression. Recent paradigm-setting studies are now revealing that non-coding RNAs, other than microRNAs, also play intriguing roles in the maintenance of chromatin structure, in the DNA damage response, and in adult human stem cell aging. In this review, we will discuss the complex inter-dependent relationships am...
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Packing of the eukaryotic genome into chromatin poses an accessibility problem for the DNA repair machinery. Chromatin structure has to be changed for the repair to occur, and we are beginning to discover how different chromatin modifying mechanisms facilitate DNA repair in the chromatin context. On the other hand, the repair-related changes in chromatin should be transient, and a particular ch...
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The DNA microarray-based technique has been developed to semi-quantitatively measure the in vivo global chromatin condensation state at the resolution of a gene. Chromatin was fractionated due to the differential solubility of histone H1-containing and histone H1-free nucleosomes. A set of genes non-randomly distributed between histone H1-free (uncondensed or open) and histone H1-containing (co...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.771.1